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For example, in the forehead, above the nose, behind and between eyes27/1/However, trying to treat sinus headaches with just caffeine is generally considered a bad idea Not only would this not address the cause of your sinus pain, it can be a headache trigger, says Mayo ClinicAnd it could bring on a whole new type of headache pain sparked by caffeine withdrawal, explains the US National Library of MedicineThe increase of pressure due to accumulated mucus can make it difficult to breathe and pave the way for throbbing headaches Because of this common symptom combination, Advil Sinus Congestion and Pain Reliever has been dubbed the best medicine for sinus pressure because it targets both pain and congestion effectively Excedrin Sinus Headache 24 Caplets Sinus headache medicine for high blood pressure